Cytogenetics is considered one of the most valuable prognostic determinants in acute myeloid leukemia (AML). However, many studies on which this assertion is based were limited by relatively small sample sizes or varying treatment approach, leading to conflicting data regarding the prognostic implications of specific cytogenetic abnormalities. The Medical Research Council (MRC) AML 10 trial, which included children and adults up to 55 years of age, not only affords the opportunity to determine the independent prognostic significance of pretreatment cytogenetics in the context of large patient groups receiving comparable therapy, but also to address their impact on the outcome of subsequent transplantation procedures performed in first complete remission (CR).
On the basis of response to induction treatment, relapse risk, and overall survival, three prognostic groups could be defined by cytogenetic abnormalities detected at presentation in comparison with the outcome of patients with normal karyotype.
AML associated with t(8;21), t(15;17) or inv(16) predicted a relatively favorable outcome. Whereas in patients lacking these favorable changes, the presence of a complex karyotype, -5, del(5q), -7, or abnormalities of 3q defined a group with relatively poor prognosis. The remaining group of patients including those with 11q23 abnormalities, +8, +21, +22, del(9q), del(7q) or other miscellaneous structural or numerical defects not encompassed by the favorable or adverse risk groups were found to have an intermediate prognosis.
ADD1 Antibody |
1-CSB-PA001348GA01HU |
Cusabio |
|
|
|
Description: A polyclonal antibody against ADD1. Recognizes ADD1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC |
ADD1 Antibody |
1-CSB-PA006900 |
Cusabio |
|
|
|
Description: A polyclonal antibody against ADD1. Recognizes ADD1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000 |
ADD1 Antibody |
32329-100ul |
SAB |
100ul |
EUR 252 |
ADD1 siRNA |
20-abx900187 |
Abbexa |
|
|
|
ADD1 siRNA |
20-abx906840 |
Abbexa |
|
|
|
ADD1 siRNA |
20-abx906841 |
Abbexa |
|
|
|
ADD1 Antibody |
AF6276 |
Affbiotech |
200ul |
EUR 304 |
Description: ADD1 Antibody detects endogenous levels of total ADD1. |
ADD1 Antibody |
DF6484 |
Affbiotech |
200ul |
EUR 304 |
Description: ADD1 Antibody detects endogenous levels of total ADD1. |
ADD1 antibody |
20R-2029 |
Fitzgerald |
50 ug |
EUR 281 |
Description: Rabbit polyclonal ADD1 antibody |
ADD1 antibody |
20R-2353 |
Fitzgerald |
50 ug |
EUR 281 |
Description: Rabbit polyclonal ADD1 antibody |
ADD1 antibody |
70R-15595 |
Fitzgerald |
50 ul |
EUR 435 |
Description: Rabbit polyclonal ADD1 antibody |
ADD1 antibody |
70R-30557 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal ADD1 antibody |
ADD1 antibody |
70R-31329 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal ADD1 antibody |
ADD1 antibody |
70R-51430 |
Fitzgerald |
100 ul |
EUR 244 |
Description: Purified Polyclonal ADD1 antibody |
ADD1 cloning plasmid |
CSB-CL001348HU-10ug |
Cusabio |
10ug |
EUR 233 |
|
Description: A cloning plasmid for the ADD1 gene. |
ADD1/ADD2 Antibody |
1-CSB-PA000825 |
Cusabio |
|
|
|
Description: A polyclonal antibody against ADD1/ADD2. Recognizes ADD1/ADD2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IP, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IP:2-5ug/mglysate.IF:1/200-1/1000.ELISA:1/40000 |
ADD1 Polyclonal Antibody |
ES4673-50ul |
ELK Biotech |
50ul |
EUR 207 |
Description: A Rabbit Polyclonal antibody against ADD1 from Human/Mouse/Rat. This antibody is tested and validated for IHC, IF, WB, ELISA |
ADD1 Polyclonal Antibody |
ES4673-100ul |
ELK Biotech |
100ul |
EUR 279 |
Description: A Rabbit Polyclonal antibody against ADD1 from Human/Mouse/Rat. This antibody is tested and validated for IHC, IF, WB, ELISA |
Anti-ADD1 antibody |
STJ22515 |
St John's Laboratory |
100 µl |
EUR 277 |
Description: Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. |
Polyclonal ADD1 Antibody |
APR14816G |
Leading Biology |
0.05ml |
EUR 484 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ADD1 . This antibody is tested and proven to work in the following applications: |
ADD1 Polyclonal Antibody |
ABP53674-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
Description: A polyclonal antibody for detection of ADD1 from Human, Mouse, Rat. This ADD1 antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Adducin ? around the non-phosphorylation site of T445 |
ADD1 Polyclonal Antibody |
ABP53674-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
Description: A polyclonal antibody for detection of ADD1 from Human, Mouse, Rat. This ADD1 antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Adducin ? around the non-phosphorylation site of T445 |
ADD1 Polyclonal Antibody |
ABP53674-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
Description: A polyclonal antibody for detection of ADD1 from Human, Mouse, Rat. This ADD1 antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Adducin ? around the non-phosphorylation site of T445 |
ADD1 (pS726) Antibody |
20-abx000248 |
Abbexa |
-
EUR 495.00
-
EUR 704.00
-
EUR 356.00
|
|
|
ADD1 (pS726) Antibody |
abx010351-100ug |
Abbexa |
100 ug |
EUR 439 |
|
ADD1 Rabbit pAb |
A1592-100ul |
Abclonal |
100 ul |
EUR 308 |
ADD1 Rabbit pAb |
A1592-200ul |
Abclonal |
200 ul |
EUR 459 |
ADD1 Rabbit pAb |
A1592-20ul |
Abclonal |
20 ul |
EUR 183 |
ADD1 Rabbit pAb |
A1592-50ul |
Abclonal |
50 ul |
EUR 223 |
ADD1 / ADD2 Antibody |
20-abx329729 |
Abbexa |
|
|
|
Anti-ADD1 antibody |
STJ91489 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Rabbit polyclonal to ADD1. |
ADD1 Blocking Peptide |
AF6276-BP |
Affbiotech |
1mg |
EUR 195 |
ADD1 Blocking Peptide |
DF6484-BP |
Affbiotech |
1mg |
EUR 195 |
Anti-ADD1 Antibody |
A1744-100 |
Biovision |
|
EUR 479 |
ADD1 antibody (Ser726) |
70R-30556 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal ADD1 antibody (Ser726) |
ADD1 antibody (Thr445) |
70R-31328 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal ADD1 antibody (Thr445) |
ADD1 antibody (Ser726) |
70R-37256 |
Fitzgerald |
100 ug |
EUR 349 |
Description: Rabbit Polyclonal ADD1 antibody (Ser726) |
Recombinant Adducin 1 (ADD1) |
4-RPC280Hu01 |
Cloud-Clone |
-
EUR 445.86
-
EUR 222.00
-
EUR 1396.96
-
EUR 532.32
-
EUR 964.64
-
EUR 361.00
-
EUR 3342.40
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
Description: Recombinant Human Adducin 1 expressed in: E.coli |
Recombinant Adducin 1 (ADD1) |
4-RPC280Mu01 |
Cloud-Clone |
-
EUR 472.74
-
EUR 229.00
-
EUR 1497.76
-
EUR 565.92
-
EUR 1031.84
-
EUR 379.00
-
EUR 3594.40
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
Description: Recombinant Mouse Adducin 1 expressed in: E.coli |
Phospho-ADD1 (T445) Antibody |
1-CSB-PA006899 |
Cusabio |
|
|
|
Description: A polyclonal antibody against Phospho-ADD1 (T445). Recognizes Phospho-ADD1 (T445) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/5000 |
Phospho-ADD1 (Ser726) Antibody |
CSB-PA557123- |
Cusabio |
|
EUR 335 |
|
Description: A polyclonal antibody against Phospho-ADD1 (Ser726). Recognizes Phospho-ADD1 (Ser726) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200 |
Phospho-ADD1 (Ser726) Antibody |
CSB-PA557123-100ul |
Cusabio |
100ul |
EUR 362 |
|
Description: A polyclonal antibody against Phospho-ADD1 (Ser726). Recognizes Phospho-ADD1 (Ser726) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200 |
ADD1 (Ab-726) Antibody |
CSB-PA570375- |
Cusabio |
|
EUR 335 |
|
Description: A polyclonal antibody against ADD1 (Ab-726). Recognizes ADD1 (Ab-726) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
ADD1 (Ab-726) Antibody |
CSB-PA570375-100ul |
Cusabio |
100ul |
EUR 316 |
|
Description: A polyclonal antibody against ADD1 (Ab-726). Recognizes ADD1 (Ab-726) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
ADD1 (Ab-726) Antibody |
CSB-PA592573- |
Cusabio |
|
EUR 335 |
|
Description: A polyclonal antibody against ADD1 (Ab-726). Recognizes ADD1 (Ab-726) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200 |
ADD1 (Ab-726) Antibody |
CSB-PA592573-100ul |
Cusabio |
100ul |
EUR 316 |
|
Description: A polyclonal antibody against ADD1 (Ab-726). Recognizes ADD1 (Ab-726) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200 |
Mouse ADD1 shRNA Plasmid |
20-abx969047 |
Abbexa |
|
|
|
Polyclonal ADD1 Antibody (S726) |
APG03120G |
Leading Biology |
0.1 mg |
EUR 484 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ADD1 (S726). This antibody is tested and proven to work in the following applications: |
Polyclonal ADD1 Antibody (Ser726) |
APR14819G |
Leading Biology |
0.05mg |
EUR 484 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ADD1 (Ser726). This antibody is tested and proven to work in the following applications: |
ADD1 (Ab-726) Antibody |
21189-100ul |
SAB |
100ul |
EUR 252 |
ADD1 (Ab-726) Antibody |
21189-50ul |
SAB |
50ul |
EUR 187 |
ADD1 (Phospho-Ser726) Antibody |
11182-100ul |
SAB |
100ul |
EUR 252 |
ADD1 (Phospho-Ser726) Antibody |
11182-50ul |
SAB |
50ul |
EUR 187 |
ADD1 (Ab-726) Antibody |
33115-100ul |
SAB |
100ul |
EUR 252 |
ADD1 (Ab-726) Antibody |
33115-50ul |
SAB |
50ul |
EUR 187 |
Adducin 1 (ADD1) Antibody |
20-abx130606 |
Abbexa |
-
EUR 439.00
-
EUR 133.00
-
EUR 1233.00
-
EUR 592.00
-
EUR 328.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Adducin 1 (ADD1) Antibody |
20-abx130607 |
Abbexa |
-
EUR 425.00
-
EUR 133.00
-
EUR 1205.00
-
EUR 578.00
-
EUR 328.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Adducin 1 (ADD1) Antibody |
20-abx110834 |
Abbexa |
|
|
|
Alpha-Adducin (ADD1) Antibody |
20-abx320155 |
Abbexa |
|
|
|
Rat ADD1 shRNA Plasmid |
20-abx984360 |
Abbexa |
|
|
|
Human ADD1 shRNA Plasmid |
20-abx950080 |
Abbexa |
|
|
|
Alpha-Adducin (ADD1) Antibody |
20-abx001340 |
Abbexa |
-
EUR 411.00
-
EUR 592.00
-
EUR 182.00
-
EUR 314.00
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
Alpha-Adducin (ADD1) Antibody |
abx148001-100ug |
Abbexa |
100 ug |
EUR 439 |
|
Alpha-Adducin (ADD1) Antibody |
abx010352-100ug |
Abbexa |
100 ug |
EUR 439 |
|
ADD1 (Phospho-Ser726) Antibody |
20-abx012401 |
Abbexa |
-
EUR 314.00
-
EUR 98.00
-
EUR 398.00
-
EUR 495.00
|
- 100 ug
- 10 ug
- 200 ug
- 300 µg
|
|
Adducin 1 (ADD1) Antibody |
20-abx242435 |
Abbexa |
|
|
|
Adducin 1 (ADD1) Antibody |
20-abx242436 |
Abbexa |
|
|
|
Alpha-Adducin (ADD1) Antibody |
abx224142-100ug |
Abbexa |
100 ug |
EUR 411 |
|
Adducin 1 (ADD1) Antibody |
abx332016-100ul |
Abbexa |
100 ul |
EUR 425 |
|
Adducin 1 (ADD1) Antibody |
abx332311-100ul |
Abbexa |
100 ul |
EUR 425 |
|
Adducin 1 (ADD1) Antibody |
20-abx326704 |
Abbexa |
|
|
|
anti-ADD1 (Ab-726) |
LF-PA20007 |
Abfrontier |
100 ul |
EUR 334 |
Description: Rabbit polyclonal to ADD1 |
anti-ADD1 (Phospho-Ser726) |
LF-PA20008 |
Abfrontier |
100 ul |
EUR 354 |
Description: Rabbit polyclonal to ADD1 (Phospho-Ser726) |
Phospho-ADD1 (Ser726) Antibody |
AF3276 |
Affbiotech |
200ul |
EUR 304 |
Description: Phospho-ADD1 (Ser726) Antibody detects endogenous levels of ADD1 only when phosphorylated at Serine 726. |
ADD1 Recombinant Protein (Mouse) |
RP114476 |
ABM |
100 ug |
Ask for price |
ADD1 Recombinant Protein (Mouse) |
RP114479 |
ABM |
100 ug |
Ask for price |
ADD1 Recombinant Protein (Mouse) |
RP114482 |
ABM |
100 ug |
Ask for price |
ADD1 Recombinant Protein (Rat) |
RP189308 |
ABM |
100 ug |
Ask for price |
ADD1 Recombinant Protein (Human) |
RP000580 |
ABM |
100 ug |
Ask for price |
Anti-Phospho-ADD1-(S726) antibody |
STJ22007 |
St John's Laboratory |
100 µl |
EUR 393 |
Description: Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. |
Polyclonal Phospho-ADD1-S726 Antibody |
APR12826G |
Leading Biology |
0.1 mg |
EUR 484 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Phospho-ADD1-S726 . This antibody is tested and proven to work in the following applications: |
Polyclonal ADD1 (Ab-726) Antibody |
APR14814G |
Leading Biology |
0.1ml |
EUR 484 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ADD1 (Ab-726) . This antibody is tested and proven to work in the following applications: |
Monoclonal ADD1 Antibody, Clone: 5D4H1 |
APR14815G |
Leading Biology |
0.1ml |
EUR 528 |
Description: A Monoclonal antibody against Human ADD1. The antibodies are raised in Mouse and are from clone 5D4H1. This antibody is applicable in WB and IHC, FC, ICC, E |
Polyclonal ADD1 Antibody (aa411-460) |
APR14817G |
Leading Biology |
0.05ml |
EUR 484 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ADD1 (aa411-460). This antibody is tested and proven to work in the following applications: |
Anti-ADD1 (Ab-726) Antibody |
A01575 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal ADD1 (Ab-726) Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat. |
Phospho-ADD1-S726 Rabbit pAb |
AP0196-100ul |
Abclonal |
100 ul |
EUR 384 |
Phospho-ADD1-S726 Rabbit pAb |
AP0196-200ul |
Abclonal |
200 ul |
EUR 554 |
Phospho-ADD1-S726 Rabbit pAb |
AP0196-20ul |
Abclonal |
20 ul |
Ask for price |
Phospho-ADD1-S726 Rabbit pAb |
AP0196-50ul |
Abclonal |
50 ul |
EUR 265 |
ADD1 / 2 Cell ELISA Kit |
abx595018-96tests |
Abbexa |
96 tests |
EUR 637 |
|
Human Adducin 1 (ADD1) Protein |
20-abx168875 |
Abbexa |
-
EUR 620.00
-
EUR 272.00
-
EUR 1887.00
-
EUR 746.00
-
EUR 453.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Mouse Adducin 1 (ADD1) Protein |
20-abx168876 |
Abbexa |
-
EUR 662.00
-
EUR 272.00
-
EUR 2026.00
-
EUR 787.00
-
EUR 481.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
ADD1 / ADD2 (pS726 / 713) Antibody |
20-abx329469 |
Abbexa |
|
|
|
The presence of additional cytogenetic abnormalities did not modify the outcome of patients with favorable cytogenetics. Subgroup analysis demonstrated that the three cytogenetically defined prognostic groups retained their predictive value in the context of secondary as well as de novo AML, within the pediatric age group and furthermore were found to be a key determinant of outcome from autologous or allogeneic bone marrow transplantation (BMT) in first CR. This study highlights the importance of diagnostic cytogenetics as an independent prognostic factor in AML, providing the framework for a stratified treatment approach of this disease, which has been adopted in the current MRC AML 12 trial.