Evaluation of hematology, general serum biochemistry, bone turnover markers and bone marrow cytology in a glucocorticoid treated ovariectomized sheep model for osteoporosis research

Evaluation of hematology, general serum biochemistry, bone turnover markers and bone marrow cytology in a glucocorticoid treated ovariectomized sheep model for osteoporosis research
Osteoporosis is a metabolic dysfunction characterised by a loss of bone mass and construction and rising the chance of fragility fractures, principally amongst postmenopausal girls. Sheep is a acknowledged massive animal model for osteoporosis research. An experimental group of ewes (3-Four years previous) was subjected to ovariectomy (OVX) and weekly glucocorticoid (GC) software for 24 weeks and in contrast with a sham management group. Blood and bone marrow parameters have been analyzed earlier than and 24 weeks after OVX and GC administration.
Osteopenia was confirmed by micro-computed tomography and histomorphometric evaluation of L4 vertebra in the research finish. A statistically important enhance was noticed in imply corpuscular quantity, imply cell hemoglobin and monocytes and a lower in purple blood rely and eosinophils (p<0.05). Alkaline phosphatase (ALP), gamma-glutamyl transpeptidase, magnesium and α1-globulin elevated, and creatinine, albumin, sodium and estradiol decreased (p<0.05). A slight lower of bone formation markers (bone ALP and osteocalcin) and a rise of bone resorption markers (C-terminal telopeptides of collagen kind 1 and tartrate-resistant acid phosphatase) have been noticed, however with out statistical significance. This research goals to contribute to higher data of sheep as a model for osteoporosis research and the implications that a carried out induction protocol might impose on natural metabolism.
Pulmonary fibrosis is a persistent, diffuse, interstitial lung illness involving the pulmonary interstitium, alveoli, and bronchioles brought on by varied causes. There is not any efficient therapy. Currently, exogenous bone marrow-derived mesenchymal stem cells (BM-MSCs) transplantation has attracted a lot consideration as a new stem cell remedy in the therapy of pulmonary fibrosis. Less consideration has been paid to the useful standing of endogenous BM-MSCs throughout pulmonary fibrosis. Based on abstract on the anti-pulmonary fibrosis impact of BM-MSCs and its mechanism, this assessment additional discusses the irregular adjustments of bone marrow perform in animals with pulmonary fibrosis and the function of glutamate NMDA receptor overactivation in mediating the useful inhibition of endogenous BM-MSCs induced by pulmonary fibrosis. This will present potential concepts for discovering efficient remedies for pulmonary fibrosis.

Adipose-derived stromal vascular fraction forestall bone bridge formation on development plate damage in rat (in vivo research) an experimental research

The development plate is cartilage tissue discovered on the finish of lengthy bones in kids, accountable for longitudinal bone development. Injuries to the expansion plate cartilage usually result in undesirable bony restore, ensuing in development disturbances equivalent to limb size discrepancy and angulation deformity in kids. There is at the moment no medical therapy that may totally restore an injured development plate. Tissue engineering is promising for regeneration of development plate.

Adipose-derived stromal vascular fraction spotlight the promising potential as tissue engineering remedy for inducing regeneration of injured development plate and capable of scale back the formation of bony restore that may result in deformity and limb size discrepancy. Using an animal model of development plate damage, bone bridge formation is evaluated after 28 days utilizing Enzyme-linked Immunoassay, radiology, histopathology and Immunofloresence examination.

Radiological analyses carried out by analysis of gray worth utilizing ImageJ software program and diameter bone bridge measured from the top to finish distance between unhurt development plate evaluated by histopatology examination. Enzyme-linked Immunoassay and immunofloresence are used to guage chondrocyte and chondrogenic marker throughout the defect. The consequence reveals in group with Adipose-derived stromal vascular fraction have a important decrease bone bridge formation evaluate to optimistic management group. This present research represents the primary work that has utilized this animal model to analyze whether or not Adipose-derived stromal vascular fraction can be utilized to provoke regeneration on the injured development plate.

Evaluation of hematology, general serum biochemistry, bone turnover markers and bone marrow cytology in a glucocorticoid treated ovariectomized sheep model for osteoporosis research

Research hotspots and tendencies of bone defects primarily based on Web of Science: a bibliometric evaluation

Bone defects will be seen all over the place in the clinic, however it’s nonetheless a problem for clinicians. Bibliometrics device CiteSpace relies on the precept of “co-citation evaluation idea” to disclose new applied sciences, hotspots, and tendencies in the medical subject. In this research, CiteSpace was used to carry out co-citation evaluation on authors, international locations (areas) and establishments, journals and cited journals, authors and cited literature, in addition to key phrases to disclose leaders, cooperative establishments, and research hotspots of bone defects and predict growth tendencies.
Data associated to bone defect from 1994 to 2019 have been retrieved from the Web of Science core assortment; then, we use Excel to assemble an exponential perform to foretell the quantity of annual publications; conduct a descriptive evaluation on the highest 10 journals with the most important quantity of publications; and carry out co-citation evaluation on authors, international locations (areas) and establishments, journals and cited journals, authors and cited reference, and key phrases utilizing CiteSpace V5.5 and use the Burst Detection Algorithm to carry out evaluation on the international locations (areas) and establishments and key phrases, in addition to cluster the key phrases utilizing log-likelihood ratio.
A complete of 5193 research have been retrieved, and the quantity of annual publications of bone defects confirmed an exponential perform Y = 1×10– 70e0.0829x (R2 = 0.9778). The high-yield writer was Choi Seong-Ho at Yonsei University in South Korea. The high-yielding international locations have been the USA and Germany, and the high-yielding establishments have been the Sao Paulo University and China and the Chinese Academy of Sciences which have been the rising research international locations and establishments. The research outcomes have been primarily printed in the fields of dentistry, bone, and metabolism.

Paraffin Tissue Section - Human Bone Tumor: Chondrosarcoma, Well Differentiated
T2235023-5 5 slides
EUR 262

Paraffin Tissue Section - Human Bone Tumor
T2235023 5 slides
EUR 262

Paraffin Tissue Section - Human Bone Tumor: Synovial Sarcoma
T2235023-8 5 slides
EUR 262

Paraffin Tissue Section - Human Bone Tumor: Myeloma, Plasmacytic
T2235023-7 5 slides
EUR 262

Paraffin Tissue Section - Human Bone Tumor: Giant Cell Tumor, Grade I-II
T2235023-6 5 slides
EUR 262

Paraffin Tissue Section - Human Lung Tumor
T2235152 5 slides
EUR 262

Paraffin Tissue Section - Human Skin Tumor
T2235218 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor
T2235035 5 slides
EUR 262

Paraffin Tissue Section - Human Colon Tumor
T2235090 5 slides
EUR 262

Paraffin Tissue Section - Human Liver Tumor
T2235149 5 slides
EUR 262

Paraffin Tissue Section - Human Breast Tumor
T2235086 5 slides
EUR 262

Paraffin Tissue Section - Human Kidney Tumor
T2235142 5 slides
EUR 262

Paraffin Tissue Section - Human Testis Tumor
T2235260 5 slides
EUR 262

Paraffin Tissue Section - Human Tonsil Tumor
T2235268 5 slides
EUR 262

Paraffin Tissue Section - Human Adipose Tumor
T2235003 5 slides
EUR 262

Paraffin Tissue Section - Human Adrenal Tumor
T2235004 5 slides
EUR 262

Paraffin Tissue Section - Human Bladder Tumor
T2235010 5 slides
EUR 262

Paraffin Tissue Section - Human Appendix Tumor
T2235006 5 slides
EUR 262

Paraffin Tissue Section - Human Pancreas Tumor
T2235188 5 slides
EUR 262

Paraffin Tissue Section - Human Prostate Tumor
T2235201 5 slides
EUR 262

Paraffin Tissue Section - Human Abdominal Tumor
T2235001 5 slides
EUR 262

Paraffin Tissue Section - Human Parathyroid Tumor
T2235189 5 slides
EUR 262

Paraffin Tissue Section - Human Gallbladder Tumor
T2235118 5 slides
EUR 262

Paraffin Tissue Section - Human Kidney Tumor: Wilms' Tumor
T2235142-7 5 slides
EUR 262

Paraffin Tissue Section - Human Uterus Cervix Tumor
T2235275 5 slides
EUR 262

Paraffin Tissue Section - Human Adipose Tumor: Lipoma
T2235003-1 5 slides
EUR 262

Paraffin Tissue Section - Human Angioma: Glomus Tumor
T2235011-2 5 slides
EUR 262

Paraffin Tissue Section - Human Adrenal Tumor: Adenoma
T2235004-1 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Epndymoma
T2235035-6 5 slides
EUR 262

Paraffin Tissue Section - Human Testis Tumor: Seminoma
T2235260-3 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Gliocytoma
T2235035-7 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Meningioma
T2235035-9 5 slides
EUR 262

Paraffin Tissue Section - Human Skin Tumor: Fibrosarcoma
T2235218-2 5 slides
EUR 262

Paraffin Tissue Section - Human Pancreas Tumor: Islet Cell Tumor
T2235188-3 5 slides
EUR 262

Paraffin Tissue Section - Human Adrenal Tumor: Myelolipoma
T2235004-3 5 slides
EUR 262

Paraffin Tissue Section - Human Breast Tumor: Fibroadenoma
T2235086-1 5 slides
EUR 262

Paraffin Tissue Section - Human Lung Tumor: Adenocarcinoma
T2235152-1 5 slides
EUR 262

Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma
T2235090-1 5 slides
EUR 262

Paraffin Tissue Section - Human Liver Tumor: Adenocarcinoma
T2235149-1 5 slides
EUR 262

Paraffin Tissue Section - Human Liver Tumor: Cholangiocellular Carcinoma
T2235149-2 5 slides
EUR 262

Paraffin Tissue Section - Human Appendix Tumor: Adenocarcinoma
T2235006-1 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Craniopharyngioma
T2235035-4 5 slides
EUR 262

Paraffin Tissue Section - Human Pancreas Tumor: Adenocarcinoma
T2235188-1 5 slides
EUR 262

Paraffin Tissue Section - Human Prostate Tumor: Adenocarcinoma
T2235201-1 5 slides
EUR 262

Paraffin Tissue Section - Human Tumor Cell Line: MCF-7
T2255830 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Ependymal Glioma
T2235035-5 5 slides
EUR 262

Paraffin Tissue Section - Human Abdominal Tumor: Neuofibromatosis
T2235001-7 5 slides
EUR 262

Paraffin Tissue Section - Human Skin Tumor: Malignant Melanoma
T2235218-3 5 slides
EUR 262

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Bone Marrow
T2236024Dia 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Meningioma (Fibrous)
T2235035-10 5 slides
EUR 262

Paraffin Tissue Section - Human Breast Tumor: Lobular carcinoma
T2235086-3 5 slides
EUR 262

Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma, MSH
T2235090MSH 5 slides
EUR 771

Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma, MSS
T2235090MSS 5 slides
EUR 550

Paraffin Tissue Section - Human Brain Tumor: Meningioma (Necrotic)
T2235035-11 5 slides
EUR 262

Paraffin Tissue Section – Human Breast Tumor, BRCA Characterized
T2235086BRCA 5 slides
EUR 550

Paraffin Tissue Section - Human Rectum Tumor: Adenocarcinoma, MSS
T2235206MSS 5 slides
EUR 550

Paraffin Tissue Section - Human Uterus Tumor: Adenocarcinoma, MSS
T2235274MSS 5 slides
EUR 550

Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma (Ulcer)
T2235090-3 5 slides
EUR 262

Paraffin Tissue Section - Human Stomach Tumor: Adenocarcinoma, MSS
T2235248MSS 5 slides
EUR 550

Paraffin Tissue Section - Human Parotid Tumor: Pleomorphic Adenoma
T2235190-5 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Pilocytic Astrocytoma
T2235035-13 5 slides
EUR 262

Paraffin Tissue Section - Human Breast Tumor: Mucous Adenocarcinoma
T2235086-6 5 slides
EUR 262

Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma (Mucoid)
T2235090-2 5 slides
EUR 262

Paraffin Tissue Section - Human Lung Tumor: Large Cell Carcinoma
T2235152-6 5 slides
EUR 262

Paraffin Tissue Section - Human Lung Tumor: Small Cell Carcinoma
T2235152-9 5 slides
EUR 262

Paraffin Tissue Section - Human Tonsil Tumor: Lymphoma of Tonsil
T2235268-1 5 slides
EUR 262

Paraffin Tissue Section - Human Liver Tumor: Hepatocellular Carcinoma
T2235149-4 5 slides
EUR 262

Paraffin Tissue Section - Human Pelvic Tumor: Malignant Mesothelioma
T2235193-2 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Astrocytoma Grade I
T2235035-1 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Astrocytoma Grade II
T2235035-2 5 slides
EUR 262

Paraffin Tissue Section - Human Uterus Cervix Tumor, HPV positive
T2235275HPV 5 slides
EUR 550

Paraffin Tissue Section - Human Uterus Cervix Tumor, HPV positive
T2235275HPV+ 5 slides
EUR 646.8
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Uterus Cervix Tumor, HPV negative
T2235275HPV- 5 slides
EUR 550
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Uterus Cervix Tumor, HPV negative
T2235275HPV-negative 5 slides
EUR 524

Paraffin Tissue Section - Human Uterus Cervix Tumor, HPV positive
T2235275HPV-positive 5 slides
EUR 524

Paraffin Tissue Section - Human Brain Tumor: Astrocytoma Grade III
T2235035-3 5 slides
EUR 262

Paraffin Tissue Section - Human Kidney Tumor: Clear cell carcinoma
T2235142-2 5 slides
EUR 262

Paraffin Tissue Section - Human Kidney Tumor: Renal Cell Carcinoma
T2235142-5 5 slides
EUR 262

Paraffin Tissue Section - Human Abdominal Tumor: Cysto Teratocarcinoid
T2235001-1 5 slides
EUR 262

Paraffin Tissue Section - Human Abdominal Tumor: Malignant Mesothelioma
T2235001-6 5 slides
EUR 262

Paraffin Tissue Section - Human Adrenal Tumor: Adrenal Pheochromocytoma
T2235004-2 5 slides
EUR 262

Paraffin Tissue Section - Human Thyroid Tumor: Papillary Adenocarcinoma
T2235265-7 5 slides
EUR 262

Paraffin Tissue Section - Human Colon Tumor: Non-hodgkin's lymphoma
T2235090-9 5 slides
EUR 262

Paraffin Tissue Section - Human Lung Tumor: Squamous Cell Carcinoma
T2235152-10 5 slides
EUR 262

Paraffin Tissue Section – Human Lung Tumor, EGFR/Kras Characterized
T2235152EK 5 slides
EUR 550

Paraffin Tissue Section - Human Skin Tumor: Squamous Cell Carcinoma
T2235218-7 5 slides
EUR 262

Paraffin Tissue Section – Human Colon Tumor, EGFR/Kras Characterized
T2235090EK 5 slides
EUR 550

Paraffin Tissue Section - Human Brain Tumor: Malignant Oligodendroglioma
T2235035-8 5 slides
EUR 262

Paraffin Tissue Section - Human Uterus Tumor: Endometrium Adenocarcinoma
T2235274-3 5 slides
EUR 262

Paraffin Tissue Section - Human Breast Tumor: Male Breast Hyperplasia
T2235086-4 5 slides
EUR 262

Paraffin Tissue Section - Human Tumor: Lung, 10x Visium-Characterized
T2235152-SV 1 slide
EUR 550

Paraffin Tissue Section - Human Prostate Tumor: Neoplasia of Prostate
T2235201-2 5 slides
EUR 262

Paraffin Tissue Section - Human Stomach Tumor: Squamous Cell Carcinoma
T2235248-10 5 slides
EUR 262

Paraffin Tissue Section - Human Breast Tumor: Invasive ductal carcinoma
T2235086-2 5 slides
EUR 262

Paraffin Tissue Section - Human Tumor: Breast, 10x Visium-Characterized
T2235086-SV 1 slide
EUR 550

Paraffin Tissue Section - Human Skin Tumor: Basal Cell Carcinoma (Face)
T2235218-1 5 slides
EUR 262

Paraffin Tissue Section - Human Breast Tumor: Medullarycarcinoma of Breast
T2235086-5 5 slides
EUR 262

Paraffin Tissue Section - Human Head & Neck Tumor: Squamouse Cell Carcinoma
T2235121 5 slides
EUR 256

Paraffin Tissue Section - Human Lymph Nodes Tumor: Non-Hodgkin's Lymphoma
T2235161-1 5 slides
EUR 262

Paraffin Tissue Section - Human Thyroid Tumor: Nodular Goiter of Thyroid
T2235265-5 5 slides
EUR 262

Paraffin Tissue Section - Human Stomach Tumor: Signet-Ring Cell Carcinoma
T2235248-9 5 slides
EUR 262

Paraffin Tissue Section - Human Liver Tumor: Nodulous Hepatocellular Carcinoma
T2235149-5 5 slides
EUR 262

Paraffin Tissue Section - Human Small Intestine Tumor: Duodenum Adenocarcinoma
T2235226-1 5 slides
EUR 262

Paraffin Tissue Section - Human Kidney Tumor: Papillary Renal Cell Carcinoma
T2235142-4 5 slides
EUR 262

CancerSeq™ Plus Paraffin Tissue Tumor Section: Lung
T2235152-SC 5 curls
EUR 818

Paraffin Tissue Section Panel - Human Tumor Same Tumor Type, Different Donors (5 tissues)
T8235086 5 slides
EUR 416

Paraffin Tissue Section Panel - Human Tumor, Same Tumor Type, Different Donors (5 tissues)
T8235090 5 slides
EUR 446

Paraffin Tissue Section Panel - Human Tumor, Same Tumor Type, Different Donors (5 tissues)
T8235106 5 slides
EUR 446

Paraffin Tissue Section Panel - Human Tumor, Same Tumor Type, Different Donors (5 tissues)
T8235142 5 slides
EUR 446

Paraffin Tissue Section Panel - Human Tumor, Same Tumor Type, Different Donors (5 tissues)
T8235149 5 slides
EUR 446

Paraffin Tissue Section Panel - Human Tumor, Same Tumor Type, Different Donors (5 tissues)
T8235152 5 slides
EUR 446
Among them, the Journal of Dental Research and Journal of Bone and Mineral Research have been high-quality journals that report bone defect research, however probably the most cited journal was the Clinical Orthopaedics and Related Research. Hot key phrases have been regeneration, restore, in vitro, bone regeneration, reconstruction, and graft. The key phrases that have been strongly cited in 2010-2019 have been transportation, osteogenic differentiation, proliferation, and biomaterials. After 2018, proliferation, osteogenic differentiation, stromal cells, transmission, and mechanical properties have grow to be new vocabulary. The drug supply, vascularization, osteogenic differentiation and biomaterial properties of bone defects have been anticipated to be additional studied.
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