American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies – Secondary Publication.

American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies – Secondary Publication.

Cell-based therapies, outlined right here because the supply of cells in vivo to deal with illness, have just lately gained rising public consideration as a probably promising method to revive construction and operate to musculoskeletal tissues. Although cell-primarily based remedy has the potential to enhance the therapy of issues of the musculoskeletal system, there may be additionally the potential of misuse and misrepresentation of the efficacy of such therapies. The medical literature comprises anecdotal studies and analysis research, together with internet-primarily based advertising and affected person testimonials supporting cell-primarily based remedy.

Both the American Society for Bone and Mineral Research (ASBMR) and the Orthopaedic Research Society (ORS) are dedicated to making sure that the potential of cell-primarily based therapies is realized via rigorous, reproducible, and clinically significant scientific discovery. The two organizations convened a multidisciplinary and worldwide Task Force composed of physicians, surgeons, and scientists who’re acknowledged specialists within the growth and use of cell-primarily based therapies. The Task Force was charged with defining the state-of-the artwork in cell-primarily based therapies and figuring out the gaps in information and methodologies that ought to information the analysis agenda.

The efforts of this Task Force are designed to supply researchers and clinicians with a greater understanding of the present state of the science and analysis wanted to advance the research and use of cell-primarily based therapies for skeletal tissues. The design and implementation of rigorous, thorough protocols might be crucial to leveraging these progressive therapies and optimizing medical and practical affected person outcomes. In addition to offering particular suggestions and moral issues for preclinical and medical investigations, this report concludes with a top level view to handle information gaps in how one can decide the cell autonomous and nonautonomous results of a donor inhabitants used for bone regeneration. © 2020 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

Research priorities for the administration of damaged bones of the higher limb in individuals over 50: a UK precedence setting partnership with the James Lind Alliance.

To decide analysis priorities for the administration of damaged bones of the higher limb in individuals over 50, which characterize the shared priorities of sufferers, their households, carers and healthcare professionals.A nationwide (UK) analysis precedence setting partnership.People aged 50 and over who’ve skilled a fracture of the higher limb, carers concerned of their care, household and associates of sufferers, healthcare professionals concerned within the therapy of those sufferers.Using a multiphase methodology in partnership with the James Lind Alliance over 15 months (September 2017 to December 2018), a nationwide scoping survey requested respondents to submit their analysis uncertainties.

These have been amalgamated right into a smaller variety of analysis questions. The present proof was searched to make sure that the questions had not already been answered. A second nationwide survey requested respondents to prioritise the analysis questions. A ultimate shortlist of 25 questions was taken to a multi-stakeholder workshop the place a consensus was reached on the highest 10 priorities.There have been 1898 authentic uncertainties submitted by 328 respondents to the primary survey. These authentic uncertainties have been refined into 51 analysis questions of which 50 have been judged to be true uncertainties following a overview of the analysis proof. There have been 209 respondents to the second (interim prioritisation) survey.

The prime 10 priorities embody a broad vary of uncertainties in administration and rehabilitation of higher limb fractures.The prime 10 UK analysis priorities spotlight uncertainties in how we assess outcomes, present info, obtain ache management, rationalise surgical intervention, optimise rehabilitation and present psychological assist. The breadth of those analysis areas highlights the worth of this system. This work ought to assist to steer analysis on this space for the following 5-10 years and the problem for researchers now’s to refine and ship solutions to those analysis priorities.

Bayesian methods in palliative care research: cancer-induced bone pain.

Engineering bone phenotypes in home animals: Unique assets for enhancing musculoskeletal analysis.

The utility of genetic engineering has elevated considerably in recent times, notably with the huge acceptance of CRISPR-Cas9 genome enhancing know-how. The huge utility of genome enhancing methods supplies a singular alternative for musculoskeletal investigators to think about the examination of uncommon (and different) illness phenotypes in addition to gene operate in home animals. It is especially essential to think about creating home animal fashions of bone issues during which the bone transforming course of parallels that noticed in people and since rodent fashions haven’t totally recapitulated the phenotype of the homologous human mutations.

In distinction to using bigger animal fashions, rodent experiments are less expensive and time-consuming, making genetically engineered small animal fashions (primarily rodents) broadly engaging for learning bone metabolism. However, many essential points not totally addressed in small animal fashions stay, similar to Haversian transforming, metaphyseal fracture therapeutic and the event and analysis of orthopedic implants. Once generated, a particular bone phenotype in a home massive animal mannequin has the potential to uncover new mechanistic insights into bone transforming, particular particulars of muscle-bone-tendon and ligament interactions, and present a chance for improved therapy and/or focused therapeutic interventions which are mechanism-primarily based.

Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx171443
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  • 200 ug

Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx171444
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  • 1 mg
  • 200 ug

Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx125568
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  • 100 ul
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Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx125569
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  • 100 ul
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Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx127103
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  • 100 ul
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Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx128482
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  • 100 ug
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  • 1 mg
  • 200 ug
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Bone Morphogenetic Protein 4 (BMP4) Antibody

abx230919-100ug 100 ug
EUR 577.2

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx224226-100ug 100 ug
EUR 493.2

Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx241855
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  • 100 ul
  • 50 ul

Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx242022
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  • 100 ul
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Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx111240
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  • 150 ul
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Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx109583
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  • 100 ug
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  • 20 ug
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Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx102815
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  • 100 ug
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Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx102816
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  • 100 ug
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Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx102817
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  • 100 ug
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Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx102818
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  • 100 ug
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Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx102819
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  • 100 ug
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Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx102820
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Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx102821
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  • 100 ug
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  • 200 ug
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Bone Morphogenetic Protein 4 (BMP4) Antibody

abx011757-100ul 100 ul
EUR 493.2

Bone Morphogenetic Protein 4 (BMP4) Antibody

20-abx001316
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  • 100 ul
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Bone Morphogenetic Protein 4 (BMP4) Antibody

abx016197-100ug 100 ug
EUR 493.2

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx025235-400ul 400 ul
EUR 627.6

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx025235-80l 80 µl
EUR 343.2

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx029327-400ul 400 ul
EUR 627.6

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx029327-80l 80 µl
EUR 343.2

BMP4 Antibody / Bone morphogenetic protein 4

RQ5387 100 ul
EUR 356.15
Description: The BMP4 gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [RefSeq]

BMP4 Antibody / Bone morphogenetic protein 4

R32828 100 ug
EUR 356.15
Description: Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene. It is found on chromosome 14q22-q23. The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx001316-100l 100 µl
EUR 400

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx001316-20l 20 µl
EUR 175

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx001316-50l 50 µl
EUR 275

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx011757-100g 100 µg Ask for price

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx011757-10g 10 µg
EUR 362.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx011757-200g 200 µg Ask for price

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx016197-1mg 1 mg
EUR 362.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx230919-100g 100 µg
EUR 350

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx128482-100l 100 µl
EUR 250

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx128482-1ml 1 ml
EUR 675

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx128482-200l 200 µl
EUR 312.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx129945-100l 100 µl
EUR 287.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx129945-1ml 1 ml
EUR 812.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx129945-200l 200 µl
EUR 362.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx129991-100l 100 µl
EUR 262.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx129991-1ml 1 ml
EUR 725

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx129991-200l 200 µl
EUR 337.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx109583-100l 100 µl
EUR 162.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx111240-100l 100 µl
EUR 612.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx025235-400l 400 µl
EUR 518.75

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102815-100l 100 µl
EUR 250

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102815-1ml 1 ml
EUR 675

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102815-200l 200 µl
EUR 312.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102816-100l 100 µl
EUR 262.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102816-1ml 1 ml
EUR 725

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102816-200l 200 µl
EUR 337.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102817-100l 100 µl
EUR 262.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102817-1ml 1 ml
EUR 725

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102817-200l 200 µl
EUR 337.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102818-100l 100 µl
EUR 262.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102818-1ml 1 ml
EUR 725

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102818-200l 200 µl
EUR 337.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102819-100l 100 µl
EUR 262.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102819-1ml 1 ml
EUR 725

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102819-200l 200 µl
EUR 337.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102820-100l 100 µl
EUR 287.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102820-1ml 1 ml
EUR 812.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102820-200l 200 µl
EUR 362.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102821-100l 100 µl
EUR 287.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102821-1ml 1 ml
EUR 812.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx102821-200l 200 µl
EUR 362.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx224226-100g 100 µg
EUR 362.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx175588-1096tests 10 × 96 tests Ask for price

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx175588-596tests 5 × 96 tests Ask for price

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx175588-96tests 96 tests
EUR 687.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx241855-96tests 96 tests
EUR 250

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx242022-96tests 96 tests
EUR 250

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx029327-400l 400 µl
EUR 518.75

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx125568-100l 100 µl
EUR 175

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx125568-1ml 1 ml
EUR 387.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx125568-200l 200 µl
EUR 275

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx125569-100l 100 µl
EUR 175

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx125569-1ml 1 ml
EUR 400

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx125569-200l 200 µl
EUR 275

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx171440-100l 100 µl
EUR 712.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx171440-1ml 1 ml Ask for price

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx171440-200l 200 µl Ask for price

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx171441-100l 100 µl
EUR 775

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx171441-1ml 1 ml Ask for price

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx171441-200l 200 µl Ask for price

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx171443-100l 100 µl
EUR 850

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx171443-1ml 1 ml Ask for price

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx171443-200l 200 µl Ask for price

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx432418-100g 100 µg
EUR 387.5

Bone Morphogenetic Protein 4 (BMP4) Antibody

abx402185-200g 200 µg
EUR 287.5

Bone Morphogenetic Protein 4 (BMP-4), Antibody

GWB-2FEE2E 0.1 mg Ask for price

Anti- Bone Morphogenetic Protein-2/4 (BMP-2/4) Antibody

GWB-CD5509 0.1 mg Ask for price

Bone Morphogenetic Protein 4 (BMP4) Antibody (APC)

20-abx175590
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  • 1 mg
  • 200 ug

Bone Morphogenetic Protein 4 (BMP4) Antibody (HRP)

20-abx108030
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  • 100 ug
  • 1 mg
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  • 20 ug
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Bone Morphogenetic Protein 4 (BMP4) Antibody (HRP)

abx108030-100g 100 µg
EUR 362.5

Bone Morphogenetic Protein 4 (BMP4) Antibody (HRP)

abx108030-20g 20 µg
EUR 162.5

Bone Morphogenetic Protein 4 (BMP4) Antibody (HRP)

abx108030-50g 50 µg
EUR 250

Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC)

20-abx271267
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC)

20-abx273865
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Bone Morphogenetic Protein 4 (BMP4) Antibody Pair

20-abx370805
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  • 10 × 96 tests
  • 5 × 96 tests

Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC)

20-abx106613
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC)

abx271267-1ml 1 ml
EUR 1137.5

Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC)

abx271267-200l 200 µl
EUR 462.5

Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC)

abx273865-25mg 25 mg
EUR 950

Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC)

abx273865-5mg 5 mg
EUR 400

Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC)

abx106613-100g 100 µg
EUR 362.5

Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC)

abx106613-20g 20 µg
EUR 162.5

Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC)

abx106613-50g 50 µg
EUR 250

Bone Morphogenetic Protein 4 (BMP4) Antibody Pair

abx370805-1596tests 15 × 96 tests
EUR 2000

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

20-abx271533
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  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

20-abx271598
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  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

20-abx271697
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  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

20-abx271814
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  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

20-abx273055
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  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

20-abx273101
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  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

20-abx105196
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

abx271533-1ml 1 ml
EUR 887.5

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

abx271533-200l 200 µl
EUR 387.5

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

abx271598-1ml 1 ml
EUR 887.5

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

abx271598-200l 200 µl
EUR 387.5

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

abx271697-1ml 1 ml
EUR 800

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

abx271697-200l 200 µl
EUR 362.5

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

abx271814-1ml 1 ml
EUR 737.5

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

abx271814-200l 200 µl
EUR 337.5

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

abx273055-25mg 25 mg
EUR 800

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

abx273055-5mg 5 mg
EUR 362.5

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

abx273101-25mg 25 mg
EUR 800

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

abx273101-5mg 5 mg
EUR 362.5

Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin)

abx105196-100g 100 µg
EUR 362.5

In this attitude, we interrogate the modeling of bone phenotypes in home animals and consider the function of those species within the progress of the musculoskeletal area, contemplating the excessive present choice for rodent fashions. Whatever the eventual consequence, it’s clear that current biotechnology developments in gene enhancing and the rising checklist of nicely-annotated genomes is bringing vital adjustments to the best way bone phenotypes are developed, studied and evaluated.

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