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Cell-based therapies, outlined right here because the supply of cells in vivo to deal with illness, have just lately gained rising public consideration as a probably promising method to revive construction and operate to musculoskeletal tissues. Although cell-primarily based remedy has the potential to enhance the therapy of issues of the musculoskeletal system, there may be additionally the potential of misuse and misrepresentation of the efficacy of such therapies. The medical literature comprises anecdotal studies and analysis research, together with internet-primarily based advertising and affected person testimonials supporting cell-primarily based remedy.
Both the American Society for Bone and Mineral Research (ASBMR) and the Orthopaedic Research Society (ORS) are dedicated to making sure that the potential of cell-primarily based therapies is realized via rigorous, reproducible, and clinically significant scientific discovery. The two organizations convened a multidisciplinary and worldwide Task Force composed of physicians, surgeons, and scientists who’re acknowledged specialists within the growth and use of cell-primarily based therapies. The Task Force was charged with defining the state-of-the artwork in cell-primarily based therapies and figuring out the gaps in information and methodologies that ought to information the analysis agenda.
The efforts of this Task Force are designed to supply researchers and clinicians with a greater understanding of the present state of the science and analysis wanted to advance the research and use of cell-primarily based therapies for skeletal tissues. The design and implementation of rigorous, thorough protocols might be crucial to leveraging these progressive therapies and optimizing medical and practical affected person outcomes. In addition to offering particular suggestions and moral issues for preclinical and medical investigations, this report concludes with a top level view to handle information gaps in how one can decide the cell autonomous and nonautonomous results of a donor inhabitants used for bone regeneration. © 2020 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.
Research priorities for the administration of damaged bones of the higher limb in individuals over 50: a UK precedence setting partnership with the James Lind Alliance.
To decide analysis priorities for the administration of damaged bones of the higher limb in individuals over 50, which characterize the shared priorities of sufferers, their households, carers and healthcare professionals.A nationwide (UK) analysis precedence setting partnership.People aged 50 and over who’ve skilled a fracture of the higher limb, carers concerned of their care, household and associates of sufferers, healthcare professionals concerned within the therapy of those sufferers.Using a multiphase methodology in partnership with the James Lind Alliance over 15 months (September 2017 to December 2018), a nationwide scoping survey requested respondents to submit their analysis uncertainties.
These have been amalgamated right into a smaller variety of analysis questions. The present proof was searched to make sure that the questions had not already been answered. A second nationwide survey requested respondents to prioritise the analysis questions. A ultimate shortlist of 25 questions was taken to a multi-stakeholder workshop the place a consensus was reached on the highest 10 priorities.There have been 1898 authentic uncertainties submitted by 328 respondents to the primary survey. These authentic uncertainties have been refined into 51 analysis questions of which 50 have been judged to be true uncertainties following a overview of the analysis proof. There have been 209 respondents to the second (interim prioritisation) survey.
The prime 10 priorities embody a broad vary of uncertainties in administration and rehabilitation of higher limb fractures.The prime 10 UK analysis priorities spotlight uncertainties in how we assess outcomes, present info, obtain ache management, rationalise surgical intervention, optimise rehabilitation and present psychological assist. The breadth of those analysis areas highlights the worth of this system. This work ought to assist to steer analysis on this space for the following 5-10 years and the problem for researchers now’s to refine and ship solutions to those analysis priorities.
Engineering bone phenotypes in home animals: Unique assets for enhancing musculoskeletal analysis.
The utility of genetic engineering has elevated considerably in recent times, notably with the huge acceptance of CRISPR-Cas9 genome enhancing know-how. The huge utility of genome enhancing methods supplies a singular alternative for musculoskeletal investigators to think about the examination of uncommon (and different) illness phenotypes in addition to gene operate in home animals. It is especially essential to think about creating home animal fashions of bone issues during which the bone transforming course of parallels that noticed in people and since rodent fashions haven’t totally recapitulated the phenotype of the homologous human mutations.
In distinction to using bigger animal fashions, rodent experiments are less expensive and time-consuming, making genetically engineered small animal fashions (primarily rodents) broadly engaging for learning bone metabolism. However, many essential points not totally addressed in small animal fashions stay, similar to Haversian transforming, metaphyseal fracture therapeutic and the event and analysis of orthopedic implants. Once generated, a particular bone phenotype in a home massive animal mannequin has the potential to uncover new mechanistic insights into bone transforming, particular particulars of muscle-bone-tendon and ligament interactions, and present a chance for improved therapy and/or focused therapeutic interventions which are mechanism-primarily based.
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx171443 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx171444 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx125568 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx125569 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx127103 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx128482 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx230919-100ug | Abbexa | 100 ug | EUR 577.2 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx224226-100ug | Abbexa | 100 ug | EUR 493.2 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx241855 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx242022 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx111240 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx109583 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx102815 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx102816 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx102817 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx102818 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx102819 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx102820 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx102821 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx011757-100ul | Abbexa | 100 ul | EUR 493.2 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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20-abx001316 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx016197-100ug | Abbexa | 100 ug | EUR 493.2 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx025235-400ul | Abbexa | 400 ul | EUR 627.6 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx025235-80l | Abbexa | 80 µl | EUR 343.2 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx029327-400ul | Abbexa | 400 ul | EUR 627.6 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx029327-80l | Abbexa | 80 µl | EUR 343.2 |
BMP4 Antibody / Bone morphogenetic protein 4 |
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RQ5387 | NSJ Bioreagents | 100 ul | EUR 356.15 |
Description: The BMP4 gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [RefSeq] |
BMP4 Antibody / Bone morphogenetic protein 4 |
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R32828 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene. It is found on chromosome 14q22-q23. The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx001316-100l | Abbexa | 100 µl | EUR 400 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx001316-20l | Abbexa | 20 µl | EUR 175 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx001316-50l | Abbexa | 50 µl | EUR 275 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx011757-100g | Abbexa | 100 µg | Ask for price |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx011757-10g | Abbexa | 10 µg | EUR 362.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx011757-200g | Abbexa | 200 µg | Ask for price |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx016197-1mg | Abbexa | 1 mg | EUR 362.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx230919-100g | Abbexa | 100 µg | EUR 350 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx128482-100l | Abbexa | 100 µl | EUR 250 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx128482-1ml | Abbexa | 1 ml | EUR 675 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx128482-200l | Abbexa | 200 µl | EUR 312.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx129945-100l | Abbexa | 100 µl | EUR 287.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx129945-1ml | Abbexa | 1 ml | EUR 812.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx129945-200l | Abbexa | 200 µl | EUR 362.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx129991-100l | Abbexa | 100 µl | EUR 262.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx129991-1ml | Abbexa | 1 ml | EUR 725 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx129991-200l | Abbexa | 200 µl | EUR 337.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx109583-100l | Abbexa | 100 µl | EUR 162.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx111240-100l | Abbexa | 100 µl | EUR 612.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx025235-400l | Abbexa | 400 µl | EUR 518.75 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102815-100l | Abbexa | 100 µl | EUR 250 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102815-1ml | Abbexa | 1 ml | EUR 675 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102815-200l | Abbexa | 200 µl | EUR 312.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102816-100l | Abbexa | 100 µl | EUR 262.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102816-1ml | Abbexa | 1 ml | EUR 725 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102816-200l | Abbexa | 200 µl | EUR 337.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102817-100l | Abbexa | 100 µl | EUR 262.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102817-1ml | Abbexa | 1 ml | EUR 725 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102817-200l | Abbexa | 200 µl | EUR 337.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102818-100l | Abbexa | 100 µl | EUR 262.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102818-1ml | Abbexa | 1 ml | EUR 725 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102818-200l | Abbexa | 200 µl | EUR 337.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102819-100l | Abbexa | 100 µl | EUR 262.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102819-1ml | Abbexa | 1 ml | EUR 725 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102819-200l | Abbexa | 200 µl | EUR 337.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102820-100l | Abbexa | 100 µl | EUR 287.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102820-1ml | Abbexa | 1 ml | EUR 812.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102820-200l | Abbexa | 200 µl | EUR 362.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102821-100l | Abbexa | 100 µl | EUR 287.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102821-1ml | Abbexa | 1 ml | EUR 812.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx102821-200l | Abbexa | 200 µl | EUR 362.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx224226-100g | Abbexa | 100 µg | EUR 362.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx175588-1096tests | Abbexa | 10 × 96 tests | Ask for price |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx175588-596tests | Abbexa | 5 × 96 tests | Ask for price |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx175588-96tests | Abbexa | 96 tests | EUR 687.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx241855-96tests | Abbexa | 96 tests | EUR 250 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx242022-96tests | Abbexa | 96 tests | EUR 250 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx029327-400l | Abbexa | 400 µl | EUR 518.75 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx125568-100l | Abbexa | 100 µl | EUR 175 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx125568-1ml | Abbexa | 1 ml | EUR 387.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx125568-200l | Abbexa | 200 µl | EUR 275 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx125569-100l | Abbexa | 100 µl | EUR 175 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx125569-1ml | Abbexa | 1 ml | EUR 400 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx125569-200l | Abbexa | 200 µl | EUR 275 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx171440-100l | Abbexa | 100 µl | EUR 712.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx171440-1ml | Abbexa | 1 ml | Ask for price |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx171440-200l | Abbexa | 200 µl | Ask for price |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx171441-100l | Abbexa | 100 µl | EUR 775 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx171441-1ml | Abbexa | 1 ml | Ask for price |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx171441-200l | Abbexa | 200 µl | Ask for price |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx171443-100l | Abbexa | 100 µl | EUR 850 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx171443-1ml | Abbexa | 1 ml | Ask for price |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx171443-200l | Abbexa | 200 µl | Ask for price |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx432418-100g | Abbexa | 100 µg | EUR 387.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody |
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abx402185-200g | Abbexa | 200 µg | EUR 287.5 |
Bone Morphogenetic Protein 4 (BMP-4), Antibody |
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GWB-2FEE2E | GenWay Biotech | 0.1 mg | Ask for price |
Anti- Bone Morphogenetic Protein-2/4 (BMP-2/4) Antibody |
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GWB-CD5509 | GenWay Biotech | 0.1 mg | Ask for price |
Bone Morphogenetic Protein 4 (BMP4) Antibody (APC) |
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20-abx175590 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody (HRP) |
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20-abx108030 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody (HRP) |
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abx108030-100g | Abbexa | 100 µg | EUR 362.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (HRP) |
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abx108030-20g | Abbexa | 20 µg | EUR 162.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (HRP) |
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abx108030-50g | Abbexa | 50 µg | EUR 250 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC) |
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20-abx271267 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC) |
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20-abx273865 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody Pair |
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20-abx370805 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC) |
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20-abx106613 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC) |
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abx271267-1ml | Abbexa | 1 ml | EUR 1137.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC) |
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abx271267-200l | Abbexa | 200 µl | EUR 462.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC) |
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abx273865-25mg | Abbexa | 25 mg | EUR 950 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC) |
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abx273865-5mg | Abbexa | 5 mg | EUR 400 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC) |
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abx106613-100g | Abbexa | 100 µg | EUR 362.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC) |
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abx106613-20g | Abbexa | 20 µg | EUR 162.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (FITC) |
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abx106613-50g | Abbexa | 50 µg | EUR 250 |
Bone Morphogenetic Protein 4 (BMP4) Antibody Pair |
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abx370805-1596tests | Abbexa | 15 × 96 tests | EUR 2000 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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20-abx271533 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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20-abx271598 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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20-abx271697 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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20-abx271814 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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20-abx273055 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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20-abx273101 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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20-abx105196 | Abbexa |
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Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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abx271533-1ml | Abbexa | 1 ml | EUR 887.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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abx271533-200l | Abbexa | 200 µl | EUR 387.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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abx271598-1ml | Abbexa | 1 ml | EUR 887.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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abx271598-200l | Abbexa | 200 µl | EUR 387.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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abx271697-1ml | Abbexa | 1 ml | EUR 800 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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abx271697-200l | Abbexa | 200 µl | EUR 362.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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abx271814-1ml | Abbexa | 1 ml | EUR 737.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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abx271814-200l | Abbexa | 200 µl | EUR 337.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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abx273055-25mg | Abbexa | 25 mg | EUR 800 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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abx273055-5mg | Abbexa | 5 mg | EUR 362.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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abx273101-25mg | Abbexa | 25 mg | EUR 800 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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abx273101-5mg | Abbexa | 5 mg | EUR 362.5 |
Bone Morphogenetic Protein 4 (BMP4) Antibody (Biotin) |
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abx105196-100g | Abbexa | 100 µg | EUR 362.5 |
In this attitude, we interrogate the modeling of bone phenotypes in home animals and consider the function of those species within the progress of the musculoskeletal area, contemplating the excessive present choice for rodent fashions. Whatever the eventual consequence, it’s clear that current biotechnology developments in gene enhancing and the rising checklist of nicely-annotated genomes is bringing vital adjustments to the best way bone phenotypes are developed, studied and evaluated.